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Cetyl Mobility and Other Products for Auto Immune System, Arthritis, Fibromyalgia Disorders

General Description: PDF Fact Sheet on Cetylmobility

This natural synergistic nutrient formula of essential minerals, long-chain fatty acid methyl esters, and Type II collagen enhances mobility for the moving joints of the body, restoring free movement and providing structural material in rebuilding healthy joint cartilage. The result of increased joint lubrication and cartilage reformation is to reduce the nagging effects of overused, aged or strained joints. The fatty acid cetyl ester formulation seems to function first as an effective lubricant for the joints. The Type II collagen in this nutrient formula supports the careful reconstruction of damaged joint tissues, including tendons, ligaments, and cartilage.

Magnesium Chelate: Important mineral in binding ATP. Required for phosphorylation reactions in glycolysis. The proper activity of numerous Mg-requiring enzymes is effected by the magnesium level in blood. Magnesium is required at various steps in the synthesis of DNA, RNA, and protein.

Zinc: Biological catalyst in many enzyme systems. Speculation: zinc supplements raise the zinc level within the joints themselves, thus having an anti-inflammatory effect at the very site of trouble.

Copper: This mineral reduces swelling and redness on inflamed joints. Copper activates superoxide dismutase, a powerful free-radical scavenger.

Manganese: National Research Council set adequate dietary intake at 2.5-5 mg/day. Mn necessary for enzymatic syntheses of mucopolysaccharide, which is deficient in rheumatoid arthritis. Mn is a trace mineral, plays role in activating numerous enzymes. It acts as a catalyst in synthesizing fatty acids. It is necessary for normal skeletal development.

Cetyl Myristoleate (C16 ester of cis-9-unsaturated C14 fatty acid): Cetyl myristoleate acts as a joint lubricant. It enhances joint mobility by thinning the natural joint lubricants that may have hardened due to aging and stress. Enhances mobility while a healthy balance of collagen/mucopolysaccharide/water in joint cartilage is being achieved through proper nutrition and dietary supplementation.

Cetyl myristoleate acts first, as a surfactant to lubricate synovial fluids, second, to regulate prostaglandin and leukotriene production to decrease inflammation, and last, as an immuno-modulator of hyper-immune responses such as that found in rheumatoid arthritis.

In a multicentered double-blind, randomized, placebo-controlled parallel trail of 431 patients[1] is reported: “The results of this trial suggest that cetyl myristoleate and cetyl myristoleate supporting formulas may be beneficial in the treatment of many forms of arthritic based diseases, including psoriatic arthritis.” “Cetyl myristoleate & supporting formulas produced the best treatment response by a factor of 72.8% more patients than did placebo.” “...it is obvious that there is a statistically significant improvement in the use of the cetyl myristoleate with supporting formulas.” This trial “...showed the majority of patients responding to cetyl myristoleate and cetyl myristoleate supporting formulas did so within the first three weeks.” “Cetyl myristoleate and cetyl myristoleate supporting formulas were well tolerated in this trial. This finding is not unexpected as cetyl myristoleate and the cetyl myristoleate supporting formula components are naturally occurring and have been used as diet supplementation for many years and are widely available singularly and in various combinations.” “In summary, cetyl myristoleate and cetyl myristoleate supporting formulas appear to be beneficial in the treatment of a wide range of arthritic conditions including long standing and refractive cases.” (Siemandi 1997)

Cetyl Myristate (C16 ester of C14 fatty acid): Cetyl myristate acts as a joint lubricant.

Cetyl Palmitoleate (C16 ester of cis-9-unsaturated C16 fatty acid): Cetyl palmitoleate acts as a joint lubricant.

Cetyl Laurate (C16 ester of C12 fatty acid): Cetyl laurate acts as a joint lubricant.

Cetyl Palmitate (C16 ester of C16 fatty acid): Cetyl Palmitate acts as a joint lubricant.

Cetyl Oleate (C16 ester of cis-9-unsaturated C18 fatty acid): Cetyl oleate acts as a joint lubricant.

Type II Collagen: Contains high concentrations of mucopolysaccharides: glucosamine sulfate and chondroitin sulfate. Protects cartilage as well as rebuilds and stimulates the production of cartilage. Type II collagen is derived from the soft sternum cartilage of young chickens. Collagen II supplies enzyme inhibitors, including proteoglycans, glucosamine, and chondrointin, which stop cartilage loss caused by enzymatic degradation. Proteoglycans are hygroscopic – assisting to attract moisture to repair joint cartilage. Other components of collagen II are anti-angiogenic to minimize joint redness. Research has also isolated growth factors in collagen II that help regeneration of joint cartilage.

Collagen II mucopolysaccharides in cartilage ease swelling and improve and accelerate wound healing. The mucopolysaccharide component of cartilage is the site of initial destruction in many joint disorders. Collagen II is a powerful alleviator of joint discomfort and a potent regenerator of cartilage tissue. Collagen II enables the body to build strong, new structural support. Type II collagen knits bone and provides elasticity to joints, serving as a shock absorber.

Clinical trial of oral administration of Type II collagen to 60 patients with randomized, double-blind study[2] reported: “This controlled trial provides evidence that oral administration of small quantities of solubilized native heterologous type II collagen is both safe and can improve the clinical manifestations of active rheumatoid arthritis.” “...this study demonstrates the therapeutic efficacy of oral tolerance for a human autoimmune disease and provides the foundation for the development of oral collagen as an easily administered nontoxic treatment for rheumatoid arthritis.” “If longer term efficacy is established, oral collagen would be a preferable treatment because it is not toxic.” “There was no evidence of sensitization to collagen, as measured by antibodies to type II collagen.” (Trentham 1993)

Clinical trial (multi-site, double-blind, placebo-controlled with 274 patients) of oral administration of Type II collagen reported[3]: “Overall, there were no differences between the treatment groups in the incidence of any adverse event during this study, and no serious adverse event was attributed to CII (Type II collagen).” “There was no significant change in IgA or IgG antibody status with treatment, suggesting that sensitization to CII (Type II collagen) did not occur.” “When the aggregate group of all patients treated with any dosage of CII (Type II collagen) was compared with the total placebo group, the presence of anticollagen antibodies was significantly associated with an increased likelihood of achieving a clinical response to CII (Type II collagen).” “The phenomenon of oral tolerance represents a novel approach to the treatment of chronic, disabling autoimmune diseases. To date, no serious adverse events have been noted in animal or human studies of oral tolerance (of Type II collagen), and the simplicity and apparent safety of this form of treatment make it extremely appealing.”

Double Blind cetylmobility Testing by Dr. Jorge Flechas

    Cetyl Test Page 1

    Cetyl Test Page 2

    Cetyl Test Page 3

    Cetyl Test Page 4

 

Adjunctive Nutritional Therapies:

Omega-3 Fatty Acids (Omega-3 EPA)

Have strong anti-inflammatory properties.

"Also, researchers at Harvard University found that 1.8 grams of EPA greatly improved tenderness in the joints, and morning stiffness in individuals suffering from rheumatoid arthritis (Quillin 1987). Improvements in this study group occurred most noticeably within 12 weeks. The results of this study can be attributed to the fact that when EPA and DHA are high in the diet, there is a corresponding reduction in leudotriene production. As previously noted, leukotrienes cause inflammation in the tissues."

MSM (methylsulfonylmethane) (Anatomix)

This rich source of natural sulfur is an integral component of healthy joint cartilage. MSM is a naturally occurring organic source of nutritional sulfur and is found in all living organisms. Although MSM is found in many fresh fruits, vegetables, milk and grains, it is purportedly destroyed by food processing, cooking and storage. MSM is utilized daily by our bodies. Good health practices involve replacing essential substances that our bodies naturally deplete or diminish through illness or abuse. Maintaining elasticity and flexibility of joint cartilage requires adequate levels of MSM. In addition, MSM has been linked with healthy nutrient transport across the cell protein/lipid membrane. This enhanced flow eliminates harmful products from cells, while permitting uptake of key nutrients to promote healing. By reducing the pressure in cells, redness and swelling of joint tissues is reduced.

Vitamin B-1 (in Maximol)

"This vitamin helps prevent crosslinking - the abnormal bonding and stiffening of collagen and elastin, the ‘protein glue’ in the white fibers of our tendons, bones, cartilage, skin, and all other connective tissue"

Vitamin B-3 (niacin, nicotinic acid, niacinamide, inositol hexanicotinate) (in Maximol)

Is a vasodialator (assists in widening arteries) to promote blood flow. "Early research by Dr. William Kaufman (1949) had demonstrated niacin's ability to diminish the pain associated with arthritis" Niacin is intimately involved with more than 50 metabolic reactions in the body.

Vitamin B-5 (calcium pantothenate) (in Maximol)

Involved in Krebs Cycle.In a study by Dr. David W. Twickenham (1980, p211) "…highly significant effects were recorded for calcium pantothenate (B-5) in reducing the duration of morning stiffness, degreee of disability and severity of pain." The subjects in the control group who received a placebo did not experience any such effects.

Vitamin B-6 (in Maximol)

According to Kronhausen and associates (1989), this nutrient helps with arthritic discomfort by shrinking swollen joint membranes and dissolving rancid fat deposits. Pain is reduced and the sufferer regains some of the lost mobility in the joints.

Selenium (in Maximol)

Selenium is a component of the protective enzyme glutathione peroxidase, a powerful free-radical scavenger."…while in rheumatoid arthritis, superoxide radicals and lipoperoxides which can be generated in the tissues and accelerate the progression of the disease,…selenium can slow down this process." (Passwater, 1980, p85-87)

Indications and Usage:

Take two capsules twice daily morning and evening for 60 days. Reduce to one capsule once or twice daily for maintenance.

For children, start with half the daily recommended dosage and slowly increase to the regular dose.

Contraindications and Warnings:

Some patients (less than 1%) receiving cetyl myristoleate treatment experience mild stomach discomfort, nausea or loose stools. This is usually caused by the inability to digest fatty acid ester oils. This can usually be remedied by supplementing the diet with lecithin to emulsify the oil, and digestive enzymes, particularly lipase, which helps break down the fatty acid ester oils.

May not be very effective if there is a known liver dysfunction. Cholecystoctomy patients or those with a history of liver or gall bladder disease or obstruction may also have trouble absorbing cetyl myristoleate. These patients will require lecithin and lipase to emulsify the cetyl myristoleate.

May take as long as 10-14 days for signs of improved free mobility, longer in some cases. During the supplement period of 3-30 days, most patients experienced enhanced joint mobility and reduction in joint pain. Many benefited from continual small daily maintenance doses without re-experiencing joint mobility problems and pain.

Recommended diet: Eat more uncooked fruits and vegetables for vitamin, minerals and antioxidants. Eat more cold water fish (salmon, herring, mackerel, albacore tuna) as a consistent source of omega-3 fatty acids. Eat less cooked animal meat to minimize consumption of arachadonic acid, which increases joint inflammation. Drink at least 2-3 quarts of water every day to hydrate the body and keep the cells functioning properly.

Cetyl Mobility the Product Ingredients:

 PDF Fact Sheet on Cetylmobility

[1] H. Siemandi, et al, (1997). “The effect of cis-9-cetyl myristoleate (CMO) and ajunctive therapy on the course of arthritic episodes in patients with various auto-immune diseases characterized by the common terminology, ‘arthritis’ and ‘psoriasis’”, Townsend Letter for Doctors & Patients Aug./Sep. 1997 #169 p. 58-63.

[2] D. Trentham, et al, (1993). “Effects of oral administration of type II collagen on rheumatoid arthritis.” Science, 261 (5129) 1727-30.

[3] M. Barnett, et al, (1998). “Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial.” Arthritis and Rheumatism, 41 (2) 290-297.

 

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