Target Organs and Levels of Evidence for NTP Technical Report Number 393
Produced from Chemtrack Database 07/23/96
CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
SODIUM FLUORIDE
7681-49-4
04/26/90 INSECTICIDE, ENAMELS, GLASS MIXES, STEEL DE-GASSING AGENT, ELECTROPLATING FLUXES, FLUORIDATION OF DRINKING WATER, DISINFECTING FERMETATION APPARATUS, PRESERVING WOOD, PASTES, MANUF. COATED PAPER, DENTAL CARIES PROPHYLACTIC (MERCK 1989) Dosed-Water R&M: 0,25,100,175 PPM Battelle Columbus Laboratory
     LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
          MR: EQUIVOCAL EVIDENCE BONE: OSTEOSARCOMA 0/80 0/50 1/50 3/80
          NON-NEOPLASTIC LESIONS: TEETH: DENTINE, INCISOR, DYSPLASIA; INCISOR, AMELOBLAST, DEGENERATION; ATTRITION; DEFORMITY; DISCOLORATION
          FR: NO EVIDENCE
          NON-NEOPLASTIC LESIONS: TEETH: DENTINE, INCISOR, DYSPLASIA; INCISOR, AMELOBLAST, DEGENERATION;ATTRITION; DEFORMITY; DISCOLORATION
           BONE: OSTEOSCLEROSIS
          MM: NO EVIDENCE
          FM: NO EVIDENCE