NTP CHEMICAL REPOSITORY <b><font color="#FF0000"> TRIETHYLOLAMINE </font>-</b>IDENTIFIERS =========== *CATALOG ID NUMBER: 000068 *CAS NUMBER: 102-71-6 * <p>BASE CHEMICAL NAME: TRIETHYLOLAMINE *PRIMARY NAME: TRIETHYLOLAMINE&nbsp;</p> <p> *CHEMICAL FORMULA: C6H15NO3 *STRUCTURAL FORMULA: (HOCH2CH2)3N *WLN: Q2N2Q2Q&nbsp;</p> <p> *<b>SYNONYMS:</b> TRIHYDROXYTRIETHYL AMINE 2,2',2''-NITRILOTRISETHANOL 2,2',2''-NITRILOTRIETHANOL 2,2',2''-NITRILOETHANOL DALTOGEN NITRILO-2,2',2''-TRIETHANOL STEROLAMIDE THIOFACO T-35 TRIAETHANOLAMIN-NG TRIETHANOLAMIN,<b>TRIETHANOLAMINE,</b> 2,2',2''-TRIHYDROXYTRIETHYLAMINE <b> TRIETHYLOLAMINE</b> TRI(HYDROXYETHYL)AMINE TRIS(2-HYDROXYETHYL)AMINE TROLAMINE TEA T-35 -PHYSICAL CHEMICAL DATA ====================== *PHYSICAL DESCRIPTIONS: LITERATURE: Pale yellow viscous liquid REPOSITORY: Clear, light yellow liquid *MOLECULAR WEIGHT: 149.19 *SPECIFIC GRAVITY: 1.1242 @ 20/4 C [031,047,205] *DENSITY: 1.126 g/mL [062] *MP (DEG C): 21.6 C [025,205] *BP (DEG C): 335.4 C @ 760 mm Hg (Decomposes) [025,031,205] *SOLUBILITIES: WATER : >=100 mg/mL @ 22 C (RAD) DMSO : >=100 mg/mL @ 22 C (RAD) 95% ETHANOL : >=100 mg/mL @ 22 C (RAD) METHANOL : Miscible [025,031] ACETONE : >=100 mg/mL @ 22 C (RAD)</p> <p>&nbsp;TOLUENE : Not available OTHER SOLVENTS: Chloroform: Soluble [017,062,205] Carbon tetrachloride: 0.4% @ 25 C [031] n-Heptane: <0.1% @ 25 C [031] Ether: 1.6 % @ 25 C [031] Benzene: 4.2% @ 25 C [031] *VOLATILITY: Vapor pressure: <0.01 mm Hg @ 20 C [055,062]; 10 mm Hg @ 205 C [042] Vapor density : 5.14 [042,055]&nbsp;</p> <p>*FLAMMABILITY(FLASH POINT): The flash point of this chemical is 185 C (365 F) [031,269,274]. It is combustible. Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. *UEL: Not available LEL: Not available&nbsp;</p> <p> *REACTIVITY: This compound can react vigorously with oxidizing materials [042]. It can also react with acids [269]. *STABILITY: This compound is hygroscopic [025,031,047,269]. It turns brown on exposure to air and light [031].&nbsp;</p> <p> *OTHER PHYSICAL DATA: Refractive index: 1.4852 @ 20 C Mild ammonia odor Viscosity: 590.5 cps @ 25 C; 65.7 cps @ 60 C pKa: 9.50 Specific gravity: 1.1258 @ 20/20 C [042]; 1.0985 @ 60/4 C [031] Boiling point: 190-193 C @ 5 mm Hg [269,274]; 277 C @ 150 mm Hg [017,047] Not volatile in steam -TOXICITY ======== *NIOSH REGISTRY NUMBER: KL9275000&nbsp;</p> <p> *TOXICITY: typ. dose mode specie amount unit other LD50 orl rat 8 gm/kg LD50 ipr mus 1450 mg/kg LD50 orl gpg 5300 mg/kg LD50 orl rbt 5160 mg/kg LD50 orl mus 7400 mg/kg *AQTX/TLM96: 1000-100 ppm&nbsp;</p> <p> <font color="#FF0000"><b> *SAX TOXICITY EVALUATION: THR: LOW via oral route. Liver and kidney damage has been demonstrated in animals from chronic exposure. MODERATE via intraperitoneal route. An experimental carcinogen. A skin and eye irritant.</b></font>&nbsp;</p> <p><font color="#FF0000"><b>*CARCINOGENICITY: Tumorigenic Data: TDLo: orl-mus 16 gm/kg/64W-C TD : orl-mus 154 gm/kg/61W-C Status: NTP Carcinogenesis Studies; on test (prechronic studies), January 1987</b></font></p> <p>&nbsp;*MUTATION DATA: test lowest dose | test lowest dose ----------- --------------- | ----------- --------------- Not available | *TERATOGENICITY: Not available *STANDARDS, REGULATIONS & RECOMMENDATIONS: OSHA: None ACGIH: None NIOSH Criteria Document: None NFPA Hazard Rating: Health (H): 2 Flammability (F): 1 Reactivity (R): 1 H2:</p> <p>&nbsp;<b><font color="#FF0000">Materials hazardous to health, but areas may be entered freely with full-faced mask self-contained breathing apparatus which provides eye protection</font> </b> (see NFPA for details). F1: Materials that must be preheated before ignition can occur (see NFPA for details). R1: Materials which are normally stable but which may become unstable at elevated temperatures and pressures or which may react with water with some release of energy but not violently (see NFPA for details).&nbsp;</p> <p><font color="#FF0000"><b> *OTHER TOXICITY DATA: Skin and Eye Irritation Data: skn-hmn 15 mg/3D-I MLD skn-rbt 560 mg/24H MLD eye-rbt 5620 ug SEV eye-rbt 10 mg MLD Status: EPA TSCA Chemical Inventory, 1986 EPA TSCA Section 8(e) Status Report 8EHQ-0478-0133 EPA TSCA Test Submission (TSCATS) Data Base, December 1986 Meets criteria for proposed OSHA Medical Records Rule -OTHER DATA (Regulatory)</b></font> ======================= *PROPER SHIPPING NAME (IATA): Not restricted *UN/ID NUMBER: *HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP: *LABELS REQUIRED: *PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY: CARGO : PKG. INSTR.: MAXIMUM QUANTITY: *SPECIAL PROVISIONS:&nbsp;</p> <p> *USES: Fatty acid soaps used in dry cleaning, cosmetics, household detergents, emulsions, wool scouring, textile antifume agent and water repellent, dispersion agent, corrosion inhibitor, softening, emulsifier, humectant and plasticizer, chelating agent, rubber accelerator, pharmaceutical alkalizing agent and catalyst for condensation.&nbsp;</p> <p> *COMMENTS: Not available <font color="#FF0000"> -HANDLING PROCEDURES =================== <b> *ACUTE/CHRONIC HAZARDS: When heated to decomposition, this compound emits toxic fumes of CO, CO2 and NOx. This compound is corrosive and causes burns. It is readily absorbed through the skin. Vapor or mist is irritating to the eyes, mucous membranes and upper respiratory tract [269].</b></font> </p> <p>*MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.</p> <p><font color="#FF0000"><b>&nbsp;*RECOMMENDED GLOVE MATERIALS:</b></font> Recommended Glove Type For Use With Neat (Undiluted) Chemical: Recommendations based on permeation test results are made for handling the neat (undiluted) chemical. If this chemical makes direct contact with your glove, or if a tear, puncture or hole develops, replace them at once. Suggested Glove Type (RAD) Model Number Thickness Breakthrough Time Latex Ackwell 0.15 mm 480 min. Butyl rubber North B-174 0.64 mm 480 min. Nitrile Edmont 37-155 0.36 mm 480 min. Neoprene Edmont 0.51 mm 480 min.</p> <p>&nbsp;<font color="#FF0000">*RECOMMENDED RESPIRATOR:</font> Where the neat test chemical is weighed and diluted, wear a NIOSH- approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. Splash proof safety goggles should be worn while handling this chemical. Alternatively, a full face respirator, equipped as above, may be used to provide simultaneous eye and respiratory protection. *OTHER: Not available *STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. *SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsi- ble person) has verified that the area has been properly cleaned. *DISPOSAL AND WASTE TREATMENT: Not available -EMERGENCY PROCEDURES ====================&nbsp;</p> <p>*<font color="#FF0000"><b>SKIN CONTACT: </b> IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. *INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever</font> possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Respirator Recommendation. *EYE CONTACT: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.&nbsp;</p> <p> *<font color="#FF0000"><b>INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems</b></font>. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. *SYMPTOMS: Symptoms of exposure to this compound may include a burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting [269]. -SOURCES ======= *SOURCES: [015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects of Chemical Substances. Microfiche Ed. National Institute for Occupational Safety and Health. Cincinnati, OH. Quarterly Updates. KL9275000. [017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton, FL. 1986. p. C-531; #14481. [025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. Chapman and Hall. New York. 1982. Vol. 5, p. 5632; #T-04426. [031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co. Rahway, NJ. 1983. p. 1381; #9476. [039] Boublik, T., V. Fried and E. Hala. The Vapor Pressures of Pure Substances. p. 623. [042] Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed. Van Nostrand Reinhold. New York. 1984. p. 2653. [047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on Organic Compounds. CRC Press, Inc. Boca Raton, FL. 1985. Vol. II, p. 394; #T01345. [053] Arthur D. Little, Inc. Health and Safety Package for Triethanolamine. Arthur D. Little, Inc. Cambridge, MA. January 13, 1983. [055] Verschueren, K. Handbook of Environmental Data on Organic Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983. pp. 1150-1151. [058] Information Handling Services. Material Safety Data Sheets Service. Microfiche Ed. Bimonthly Updates. February/March 1988. #5846-039, A-01. [062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987. pp. 1179-1180. [082] U.S. Environmental Protection Agency, Office of Toxic Substances. Toxic Substances Control Act Chemical Substance Inventory: 1985 Edition. 5 Vols. U.S. Environmental Protection Agency. Washington, D.C. January 1986. Listed. [099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles C. Thomas, Publisher. Springfield, IL. 1986. p. 944. [102] U.S. Department of Health and Human Services and U.S. Department of Labor. NIOSH/OSHA Occupational Health Guidelines for Chemical Hazards. 3 Vols. DHHS (NIOSH) Publication No. 81-123. January, 1981. Vol. 2. [107] Occupational Health Services, Inc. Hazardline. Occupational Health Services, Inc. New York. Listed. [110] Oak Ridge National Laboratory. Environmental Mutagen Information Center (EMIC), Bibliographic Data Base. Oak Ridge National Laboratory. Oak Ridge, TN. Listed. [120] Oak Ridge National Laboratory. Environmental Teratogen Information Center (ETIC), Bibliographic Data Base. Oak Ridge National Laboratory. Oak Ridge, TN. Not listed. [151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology of Commercial Products. 5th Ed. Williams and Wilkins, Co. Baltimore. 1984. p. II-106; #66. [195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and Fragrance Assn. Inc. Washington. 1982. p. 323. [205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed. McGraw-Hill Book Company. New York. 1985. p. 7-657; #t462. [269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data. Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985. p. 1747-C. [274] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI. 1986. p. 1299; #T5,830-0. [301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis and Treatment. 11th Ed. Lange Medical Publications. Los Altos, CA. 1983. p. 231. [371] U.S. Coast Guard, Department of Transportation. CHRIS Hazardous Chemical Data. U.S. Coast Guard. Washington, D.C. 1985. Vol. 2. [430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene and Toxicology. Vol. 2. Third Revised Edition. John Wiley and Sons. New York. 1981. Vol. II-B; pp. 3166, 3167, 3169. [610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to Industrial Chemicals Covered Under Major Federal Regulatory and Advisory Programs. Roytech Publications, Inc. Burlingame, CA. 1990. Section 3, p. 37. [620] United States National Toxicology Program. Chemical Status Report. NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990. Listed. -------------------------------------------------------------