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Sodium lauryl sulfate and
recurrent aphthous ulcers. A preliminary
study.
Herlofson BB, Barkvoll
P.
Department of Oral Surgery and Oral Medicine, Dental
Faculty, University of Oslo, Norway.
Sodium lauryl sulfate (SLS),
a synthetic detergent commonly used in dentifrices, is an effective
denaturant. The aim of the present study was to investigate the effect
of SLS in patients with recurrent aphthous ulcers (RAU). Ten patients
with multiple minor RAU participated in the study. The mean incidence of
RAU was 17.8 during a 3-month period before the study. The patients used
a dentifrice containing 1.2% SLS for a test period of 3 months followed
by a dentifrice without SLS for the same time period. The results showed
a statistically significant decrease in the number of aphthous ulcers
from 14.3 after using the SLS-containing dentifrice to 5.1 ulcers after
brushing with the SLS-free dentifrice (p < 0.05). It is suggested
that the denaturing effect of SLS on the oral mucin layer, with exposure
of the underlying epithelium, induces an increased incidence of
RAU.
Publication Types:
PMID: 7825393 [PubMed -
indexed for MEDLINE]
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The effect of two toothpaste
detergents on the frequency of recurrent aphthous
ulcers.
Herlofson BB, Barkvoll
P.
Department of Oral Surgery and Oral Medicine, Dental
Faculty, University of Oslo, Norway.
The aim of the present
clinical double-blind crossover study was to investigate the effect of
two different toothpaste detergents, sodium lauryl sulfate (SLS) and
cocoamidopropyl betaine (CAPB), as compared with a detergent-free paste,
on 30 patients with frequent occurrences of recurrent aphthous ulcers.
The study consisted of three 6-week periods during which the patients
brushed twice daily with the different test toothpastes. The
localization and number of new ulcers were assessed. A significantly
higher frequency of aphthous ulcers was demonstrated when the patients
brushed with an SLS- than with a CAPB-containing or a detergent-free
placebo paste. An SLS-free toothpaste may thus be recommended for
patients with recurrent aphthous ulcers.
Publication Types:
PMID: 8811135 [PubMed -
indexed for MEDLINE]
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